The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and somewhat soluble in alcohol. The molecular excess weight is 406.37. Its molecular method is C18H21NO3•H3PO4 • ½ H2O, and it's got the following chemical composition.
Hyperexcitability and irregular actions are documented in patients pursuing an individual administration of promethazine HCl. Consideration need to be provided towards the discontinuation of promethazine HCl and also to using other medication if these reactions arise.
Your healthcare company may well do blood checks to look for adrenal gland problems. Phone your healthcare service provider without delay When you've got any of those signs and symptoms:
Medical research of Promethazine formulations didn't contain adequate figures of topics aged 65 and more than to find out whether they reply otherwise from younger subjects. Other described scientific knowledge hasn't discovered distinctions in responses concerning the aged and youthful people.
For preoperative medication young children require doses of 0.five mg per pound of physique bodyweight together with the appropriately reduced dose of narcotic or barbiturate and the right dose of an atropine-like drug.
Codeine: Dosage of codeine Really should not be Improved if cough fails to reply; an unresponsive cough must be reevaluated in five times or sooner for doable underlying pathology, which include foreign physique or decrease respiratory tract disease.
Promethazine HCl and Codeine Phosphate Oral Solution exposes clients and also other end users to your hazards of opioid dependancy, abuse, and misuse, which can cause overdose and death. Reserve Promethazine HCl and Codeine Phosphate Oral Alternative to be used in Grownup patients for whom the advantages of cough suppression are expected to outweigh the challenges, and in whom an enough assessment with the etiology from the cough has actually been created.
Serious hypotension generally responds for the administration of norepinephrine or phenylephrine. EPINEPHRINE Shouldn't be Applied, considering the fact that its use in a very client with partial adrenergic here blockade may well additional lessen the blood pressure.
Some medicines might affect how promethazine is effective or promethazine could impact how your other medicines do the job. Know the medicines you're taking. Keep a listing of them along with you to indicate your Health care Expert. Primarily convey to your healthcare Qualified if you take:
Lifetime-threatening respiratory depression and death have happened in young children who obtained codeine. The majority of the described conditions happened adhering to tonsillectomy and/or adenoidectomy, and plenty of of the children had proof of being an extremely-quick metabolizer of codeine due to a CYP2D6 polymorphism [see Warnings and Safety measures (5.
Concomitant administration of Promethazine items with other respiratory depressants has an Affiliation with respiratory depression, and from time to time Loss of life, in pediatric individuals.
Overdose of codeine in Grownups has been related to fatal respiratory depression, and the use of codeine in children younger than twelve several years of age continues to be connected to lethal respiratory despair when used as suggested [see Warnings and Safeguards (5.
Respiratory melancholy leading to arrest, coma, and Demise has happened with the use of codeine antitussives in younger children, notably in the beneath-a person-yr infants whose capacity to deactivate the drug is not really completely formulated.
Stay clear of the use of Promethazine HCl and Codeine Phosphate Oral Option in adolescents 12 to eighteen a long time of age who have other threat elements that may enhance their sensitivity to the respiratory depressant effects of codeine. Threat things consist of situations linked to hypoventilation, like postoperative position, obstructive sleep apnea, obesity, critical pulmonary illness, neuromuscular condition, and concomitant usage of other medicines that lead to respiratory despair.